A Different Approach to Difficult to Treat Depression

Get well and stay well — with SYMMETRY®

If you’re struggling with depression (unipolar or bipolar) that is difficult to treat and traditional treatments have failed to provide you with relief, there's another way forward.

Woman by the water
Difficult to Treat Depression Stats

What is Difficult to Treat Depression?

Difficult to Treat Depression* (DTD) is a failure to achieve response or remission following two or more treatments used at an adequate dose and duration. More than 2.7 million American adults suffer from the burden of Difficult to Treat Depression.

Fewer People Find Relief With Each Medication They Try

Depression may continue even with traditional treatments, such as medication or talk therapy. In fact, more than 6 in 10 people fail to successfully achieve complete relief from major depression with their first medication.

SYMMETRY® is indicated for the adjunctive long-term treatment of chronic or recurrent depression for patients 18 years of age or older who are experiencing a major depressive episode and have not had an adequate response to four or more adequate antidepressant treatments.

When compared to people with depression,
people with DTD have:

icon for 2.5x

more very severe depression

98% icon

increase in hospitalization risk

Man wearing Symmetry VNS device
A Unique Approach

VNS Therapy® (Vagus Nerve Stimulation Therapy) for Difficult to Treat Depression

SYMMETRY® is not a drug. It is not brain surgery. It uses the natural pathways in your body. VNS Therapy® is a device that works by stimulating the vagus nerve.

What makes SYMMETRY effective:

  1. The vagus nerve is connected to areas of the brain that control mood.
  2. SYMMETRY works by regularly sending mild pulses through a thin wire directly to the vagus nerve in the neck.
  3. Through these pulses, SYMMETRY has been shown to improve depression symptoms.

There’s Safety in Our Numbers

VNS Therapy® is FDA approved and has been extensively studied across multiple conditions

Years of patient experience with VNS Therapy Technology


Patients implanted across multiple diseases

Real People. Real Stories.

Kelsey, Art Museum Curator and VNS Therapy™ Patient

Michael, VNS Therapy™ Patient, C'oeur D'Alene, Idaho

Marilu, Art Educator and VNS Therapy™ Patient Washington, D.C.

It’s time to treat depression differently

Get in Touch Today