Highest number of publications among neuromodulation therapies in epilepsy4
High number of neuromodulation implants for DRE3
The longest experience in DRE
Based on studies comparing effects of VNS Therapy™ compared to pre-VNS Therapy™, or VNS Therapy™ + treatment-as-usual compared to treatment-as-usual alone, some people with VNS Therapy™ have experienced benefits that include:
VNS Therapy™ has been shown to reduce seizures as early as 3 months and reductions increase over time.9
Benefits of VNS Therapy™ for Adults Benefits of VNS Therapy™ for Paediatrics
Percent change in seizure frequency by seizure type (median with 95% CI)
VNS Therapy™ is an approved treatment option for both paediatric and adult patients with drug-resistant epilepsy.2
The VNS Therapy™ System includes a pulse generator that is implanted under the skin and connected via leads to the left vagus nerve at the carotid sheath. The generator sends mild pulses through the vagus nerve to the brain.10 VNS Therapy™ can lead to fewer seizures, shorter seizures and better recovery after seizures, as well as improvements in quality of life, depressive symptoms, cognition and memory.5,7,8
Helps prevent seizures
Stimulation is delivered at regular intervals all day, every day2,10
Responds to rapid increases in heart rate
An extra dose of therapy is automatically delivered at the sign of a rapid increase in heart rate, which may be associated with seizures2,10,11
*Only available in Models 106, 1000 and 1000-D
Delivers on-demand treatment
Stimulation is manually delivered by swiping the VNS Therapy™ Magnet over the area of the device to help stop or shorten a seizure once it starts2,10
Enhanced programming options available with the latest VNS Therapy™ technology
Create two independent sets of therapy parameters at different times during a 24-hour period.
After the Day-Night program has been defined, the generator will alternate between the 2 independent parameter sets on a daily basis. This feature provides the physician with the ability to further customise the delivery of VNS Therapy™ to accomodate each individual patient's needs after a target level has been established for the patient.2
Enables the programming of the generator so that it automatically increases stimulation therapy parameters while the patient is in the comfort of their home.
This feature is intended to be used during the titration phase and could potentially reduce the number of appointments the patient may need to travel to and from the clinic for programming visits only.2
The unique mechanism of action involves the bottom-up modulation of seizure-propagating circuitry.
Vagal afferents primarily project to the nucleus tractus solitarius (NTS), which then sends fibers to other brainstem nuclei that modulate subcortical and cortical activity. This vagal afferent network is likely the neural substrate of the anti-seizure effects of VNS Therapy™.
