Quality of Life with VNS Therapy™

A stimulating rationale for VNS Therapy^TM - break the cycle of repeated anti-seizure medication (ASM) failures

At least 1/3 of epilepsy patients will not achieve seizure freedom with ASMs^2,3
Patients living with DRE suffer physical, psychological, and societal consequences of refractory seizures along with a heavy drug burden and increased mortality^4-7
Important determinants of health-related quality of life in DRE include the burden of ASM toxicity, depressive symptoms and seizure worry^8,9

The VNS Therapy™ System is indicated for use as an adjunctive therapy in reducing the frequency of seizures in patients whose epileptic disorder is dominated by partial seizures (with or without secondary generalisation) or generalised seizures that are refractory to anti-seizure medications.

VNS Therapy^™ is proven to be a safe adjunctive treatment and is well-tolerated by most patients without contributing to ASM toxicity^12-14

Can improve seizure control without contributing to ASM toxicity
No drug interactions—can be combined with any ASM regimen

Most common side effects

The most common side effects of VNS Therapy^™ occur during stimulation and generally become less noticeable over time for most patients¹⁵:
- Hoarseness / Voice Alteration
- Increased Coughing
- Sore Throat
- Tingling Sensation in the Neck
- Shortness of Breath
Infection is the most common complication of the procedure¹²

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Helps improve your patients' emotional well-being and overall quality of life¹⁶

Continued reduction in seizure frequency over time: 76% mean seizure frequency reduction in patients who completed 10 years of VNS Therapy™ (N=65)¹⁴

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Associated with reduced depressive symptoms¹¹

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Proven to be a safe, adjunctive treatment and is well-tolerated by most patients without contributing to ASM toxicity¹²

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Can provide improvements in seizure control with 59% reporting ≥ 50% reduction and 41% reporting ≥ 80% reduction¹⁷

VNS Therapy™ has proven safety and tolerability profile with side effects reducing over time^13,14

Safety Profile

VNS Therapy^™ has no drug interactions and does not cause drug-related toxic central nervous system side effects.¹⁵

The most common adverse events following stimulation (>5%) were voice alterations, increased coughing, pharyngitis, paresthesia, dyspnea, dyspepsia, and nausea. These side effects typically occur only during stimulation and generally become less noticeable over time for most patients.^12,13,15

Infection is the most common complication of the surgical procedure. Children (<12 years of age) may have a greater risk for infection when compared to adolescent and adult patients (≥12 years).¹²

For more safety information click here.

INTENDED USE / INDICATIONS Epilepsy (Non-US) The VNS Therapy™ System is indicated for use as an adjunctive therapy in reducing the frequency of seizures in patients whose epileptic disorder is dominated by partial seizures (with or without secondary generalisation) or generalised seizures that are refractory to anti-seizure medications.

References

1. Data on file, LivaNova USA, Inc., Houston, TX. 2021. 2. Chen Z, et al. JAMA Neurol. 2018;75(3):279–86. 3. Kwan P, Brodie MJ. N Engl J Med. 2000;342:314–9. 4. Wheless JW. Epilepsy Behav. 2006;8(4):756–64. 5. Gilliam F. Neurology. 2002;58(8 suppl 5):S9–20. 6. Fisher RS, et al. Epilepsy Res. 2000;41(1):39–51. 7. Thurman DJ, et al. Epilepsia. 2017;58(1):17–26. 8. Luoni C, et al. Epilepsia. 2011;52(12):2181–91. 9. Loring DW, et al. Epilpesy Behav. 2004;5(6):976–80. 10. Data on File, E37 Pooled Calculations, LivaNova, Houston, TX. 11. Kim SJ, et al. J Clin Neurol. 2021;17(3):385–92. 12. VNS Therapy™ System Epilepsy Physician’s Manual (OUS), January 2025, LivaNova, Houston, TX. 13. Ben-Menachem E. J Clin Neurophysiol. 2001;18(5):415–8. 14. Elliott RE, et al. Epilepsy Behav. 2011;20(1):57–63. 15. VNS Therapy™ Patient’s Guide for Epilepsy (OUS), January 2025, LivaNova, Houston, TX. 16. Soleman J, et al. Epilepsy Behav. 2018;88:139–45. 17. Hamilton P, et al. Seizure. 2018;58:120–26.

VNS Therapy^TM is a Life-changer

In a survey of 200 VNS Therapy™ patients and caregivers¹:

A stimulating rationale for VNS Therapy^TM - break the cycle of repeated anti-seizure medication (ASM) failures

Stimulating life with VNS Therapy™ - helps improve your patients' emotional well-being and overall quality of life

Improvements in quality of life confirmed across 2 prospective, multicentre, clinical trials (E-36, E-37)^10*

VNS Therapy^™ is proven to be a safe adjunctive treatment and is well-tolerated by most patients without contributing to ASM toxicity^12-14

Most common side effects

VNS Therapy™ can help improve their QoL and reduce the burden of DRE

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VNS Therapy™ has proven safety and tolerability profile with side effects reducing over time^13,14

Safety Profile

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To see the other countries, please click here.

VNS TherapyTM is a Life-changer

In a survey of 200 VNS Therapy™ patients and caregivers1:

A stimulating rationale for VNS TherapyTM - break the cycle of repeated anti-seizure medication (ASM) failures

Stimulating life with VNS Therapy™ - helps improve your patients' emotional well-being and overall quality of life

Improvements in quality of life confirmed across 2 prospective, multicentre, clinical trials (E-36, E-37)10*

VNS Therapy™ is proven to be a safe adjunctive treatment and is well-tolerated by most patients without contributing to ASM toxicity12-14

Most common side effects

VNS Therapy™ can help improve their QoL and reduce the burden of DRE

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VNS Therapy™ has proven safety and tolerability profile with side effects reducing over time13,14

Safety Profile

Choose a country

To see the other countries, please click here.

VNS Therapy^TM is a Life-changer

In a survey of 200 VNS Therapy™ patients and caregivers¹:

A stimulating rationale for VNS Therapy^TM - break the cycle of repeated anti-seizure medication (ASM) failures

Improvements in quality of life confirmed across 2 prospective, multicentre, clinical trials (E-36, E-37)^10*

VNS Therapy^™ is proven to be a safe adjunctive treatment and is well-tolerated by most patients without contributing to ASM toxicity^12-14

VNS Therapy™ has proven safety and tolerability profile with side effects reducing over time^13,14