Name: AspireSR™
Brand: LivaNova
Rating: 5 (1 reviews)

AspireSR™- Advancing the treatment of drug-resistant epilepsy with responsive VNS Therapy™

Proven efficacy and safety of VNS Therapy™²
Helps stop or shorten a seizure by responding to a rapid increase in heart rate, that may be associated with seizures³
Helps prevent seizures by delivering treatment at regular intervals all day, every day³
May reduce seizure duration and seizure severity and improve post-ictal recovery¹
Improves quality of life^1,4

Normal Mode

Helps prevent seizures

Stimulation is delivered at regular intervals all day, every day^3,5

AutoStim Mode*

Responds to rapid increases in heart rate

An extra dose of therapy is automatically delivered at the sign of a rapid increase in heart rate, which may be associated with seizures^3,5,6

*Only available in Models 106, 1000 and 1000-D

VNS Therapy™ Magnet

Delivers On-Demand Treatment

Stimulation is manually delivered by swiping the VNS Therapy™ Magnet over the area of the device to help stop or shorten a seizure once it starts^3,5

The change from regular to responsive VNS Therapy™ was associated with an additional reduction in seizure frequency⁸

Based on the McHugh Classification of patients receiving VNS Therapy™:

12 out of 29 patients (41%) who had less than 50% seizure reduction with regular VNS Therapy™ reported more than 50% seizure reduction after switching to responsive VNS Therapy.™

This study was a non-controlled retrospective analysis of data where the seizure reporting is an interpretation of patients and carers.

^{*Conventional VNS Therapy™ in this article refers to models before AspireSR™ without the cardiac based seizure detection and closed loop stimulation. **Responsive VNS Therapy™ in this article refers to AspireSR™ model.}

VNS Therapy™ has proven safety and tolerability profile with side effects reducing over time^2,9

Safety Profile

VNS Therapy^™ has no drug interactions and does not cause drug-related toxic central nervous system side effects.⁵

The most common adverse events following stimulation (>5%) were voice alterations, increased coughing, pharyngitis, paresthesia, dyspnea, dyspepsia, and nausea. These side effects typically occur only during stimulation and generally become less noticeable over time for most patients.^3,5,9

Infection is the most common complication of the surgical procedure. Children (<12 years of age) may have a greater risk for infection when compared to adolescent and adult patients (≥12 years).³

For more safety information click here.

*Responsive VNS Therapy™ refers to VNS Therapy devices with AutoStim Mode enabled. Available in models 106 and 1000, 1000-D

^†Individual study example (N=28/46). Results may vary.

References
1. Orosz I, et al. Epilepsia. 2014;55(10):1576–84. 2. Elliott RE, et al. Epilepsy Behav. 2011;20(1):57–63. 3. VNS Therapy™ System Epilepsy Physician’s Manual (OUS), January 2025, LivaNova, Houston, TX. 4. Englot DJ, et al. Epilepsy Behav. 2017;66:4–9. 5. VNS Therapy™ Patient’s Guide for Epilepsy (OUS), January 2025, LivaNova, Houston, TX. 6. Fisher RS, et al. Neuromodulation. 2016;19(2):188–95. 7. Data on File, LivaNova, Houston, TX. 8. Hamilton P, et al. Seizure. 2018;58:120–6. 9. Ben-Menachem E. J Clin Neurophysiol. 2001;18(5):415–8.

VNS Therapy™ - AspireSR™

AspireSR™- Advancing the treatment of drug-resistant epilepsy with responsive VNS Therapy™

VNS Therapy™ can deliver stimulation in three ways

Normal Mode

AutoStim Mode*

VNS Therapy™ Magnet

AspireSR™ detects and responds to rapid increases in heart rate, that may be associated with a seizure³

The change from regular to responsive VNS Therapy™ was associated with an additional reduction in seizure frequency⁸

AspireSR™ Technical Sheet

VNS Therapy™ has proven safety and tolerability profile with side effects reducing over time^2,9

Safety Profile

Choose a country

To see the other countries, please click here.

VNS Therapy™ - AspireSR™

AspireSR™- Advancing the treatment of drug-resistant epilepsy with responsive VNS Therapy™

VNS Therapy™ can deliver stimulation in three ways

Normal Mode

AutoStim Mode*

VNS Therapy™ Magnet

AspireSR™ detects and responds to rapid increases in heart rate, that may be associated with a seizure3

The change from regular to responsive VNS Therapy™ was associated with an additional reduction in seizure frequency8

AspireSR™ Technical Sheet

VNS Therapy™ has proven safety and tolerability profile with side effects reducing over time2,9

Safety Profile

Choose a country

To see the other countries, please click here.

AspireSR™ detects and responds to rapid increases in heart rate, that may be associated with a seizure³

The change from regular to responsive VNS Therapy™ was associated with an additional reduction in seizure frequency⁸

VNS Therapy™ has proven safety and tolerability profile with side effects reducing over time^2,9