AspireSR™
VNS Therapy can lead to fewer seizures, shorter seizures and better recovery after seizures.


AspireSR™ detects and responds to rapid increases in heart rate, which may be associated with a seizure1
In clinical trials, over 60% of seizures treated ended during automatic stimulation.
The closer the stimulation to seizure onset, the shorter the seizure duration2
VNS Therapy™ controls seizures in 3 ways

Preventative
Normal Mode
Helps prevent seizures by delivering treatment at regular intervals all day, every day1

Responsive*
AutoStim Mode
Helps stop or shorten a seizure by responding to a rapid increase in heart rate, a potential seizure biomarker1,3,4
*Only available in models 106, 1000, and 1000-D
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On-Demand
Magnet Mode
Helps stop or shorten a seizure once it starts by passing the included VNS Therapy® Magnet over the generator1

Responsive VNS Therapy™ (AutoStim Mode) provides improvements in seizures control
Mean follow-up 13 months
p<0.001
59% reported ≥ 50% reduction in seizures
41% reported ≥ 80% reduction in seizures
Responsive VNS Therapy™ devices include Normal Mode, Magnet Mode, and AutoStim Mode. Conventional VNS Therapy devices include Normal Mode and Magnet Mode.
*Only available in models 106, 1000, and 1000-D

VNS Therapy™ de-intensifies seizures and improves patient recovery after seizures
Reduction in duration of focal seizures3
62% REDUCTION in median seizure duration
(32 seconds v 85 seconds, in patients on VNS Therapy with AutoStim compared to patients' historical data)

AspireSR™ is shown to improve quality of life2
Clinically meaningful and statistically significant improvements in overall QOL were seen at 3 months and continued to improve over time.

AspireSR™ - Advancing the treatment of drug-resistant epilepsy
- Provides the proven efficacy and safety of VNS Therapy
- Detects and responds to ictal tachycardia in an effort to stop seizures spreading in the brain
- May terminate seizures by delivering automatic stimulation when a seizure occurs
- May reduce seizure duration and seizure severity and improve post-ictal recovery
- Improves quality of life
AspireSR™ Technical Sheet
DownloadMRI Safety
The latest VNS Therapy™ technology with expanded MRI access allows patients to obtain quality MRI scans
References
1. VNS Therapy System® Epilepsy Physician’s Manual (US), May 2020, LivaNova USA, Inc. Houston, TX. 2. Data on file, LivaNova, Inc., Houston, TX. 3. Fisher RS, Afra P, Macken M, et al. Neuromodulation. 2016;19:188-195. 4. Hirsch M, Altenmüller DM, Schulze-Bonhage A. Epilepsia. 2015;56(10):1639-1647. 5. Datta P, Galla KM , Sajja K, et al. Epilepsy Behav. 2020;111:107280.